Ibogaine

Chemically, ibogaine is closely related to the B-carbolines, and particularly to harmaline and harmine. It belongs to the group of cyclic tryptamine derivatives.
Ibogaine was first isolated from the root cortex of Tabernanthe iboga in France in 1901. Ibogaine and analogous alkaloids also occur in Pandaca retusa... a dogbane species native to Madagscar. Many genera in the Family Apocynaceae, including Tabernaemontana, Voacanga, Stemmadenia, Ervatamia and Gabunea, contain ibogaine-type indole alkaloids.
Between 1940 and 1950, most research into ibogaine was conducted in France. Because it exhibited potent stimulating properties, the initial pharmacological research focused on ibogaine's neuropharmacological effects. Only later were the hallucinogenic effects more precisely studied...
Today, ibogaine is in the spotlight of neuropharmacological research because it has been shown that this alkaloid can be used to reduce and cure the addictive behavior of people dependent on other drugs (heroine, cocaine). For example, ibogaine has been found to suppress the motor activity that occurs during opiate withdrawal. It has been proposed that ibogaine, when

"ingested by opiate addicts in a single high dosage, dramatically reduces withdrawal symptoms while simultaneously causing a trip that provides the patient with such deep insights into the personal causes of the addiction that a majority of the individuals who receive such therapy can live for months without relapse. However, it should be notes that several additional sessions may be necessary before a persistent stabilization occurs."

Experiments with primates have shown that ibogaine reduces opiate addiction and partially blocks withdrawal symptoms. Although the neuropharmacological mechanism behind these effects has not yet been discovered, Deborah Mash and her team in Miami are researching this question. Ibogaine has been demonstrated to interact with numerous different receptors, and it has been concluded that this breadth of interaction is the reason for ibogaine's effectiveness in addition therapy...
Ibogaine enjoys a reputation for being an exceptionally potent and stimulating aphrodisiac.

- pp. 842- 843, The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications by by Christian R├Ątsch (1998)

Dragees Nyrdahl Ibogene
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