Mann Research Laboratories Mescaline Hydrochloride Bottle

Mescaline or 3,4,5-trimethoxyphenethylamine is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its mind-altering effects similar to those of LSD and Psilocybin.

It occurs naturally in the Peyote cactus (Lophophora williamsii),[1] and the Peruvian Torch cactus (Echinopsis peruviana), and in a number of other members of the Cactaceae plant family. It is also found in small amounts in certain members of the Fabaceae (bean) family, including Acacia berlandieri.

Peyote has been used for over 3000 years by Native Americans in Mexico.[1] Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador.

In traditional peyote preparations the top of the cactus is cut at ground level, leaving the large tap roots to grow new 'Heads'. These 'Heads' are then dried to make disk-shaped buttons. Buttons are chewed to produce the effects or soaked in water for an intoxicating drink. However, the taste of the cactus is bitter, so contemporary users will often grind it into a powder and pour it in capsules to avoid having to taste it. The usual human dosage is 200–400 milligrams of mescaline sulfate or 178–356 milligrams of mescaline hydrochloride.[3] The average 76 mm (3.0 in) button contains about 25 mg mescaline.[4]

Excerpt from Wikipedia's Mescaline

The first account (by a white) of "peyote inebriation" was published in 1897 by the distinguished Philadelphia physician and novelist Weir Mitchell. Soon after, he sent "peyote buttons" - the part of the plant growing above ground - to Havelock Ellis, a pioneer in psychological and sexual studies. Ellis had read Mitchell's narrative and soon published two influential accounts of his own experiments under the influence of peyote in the British Journal of Medicine.

The scientific examination of peyote stimulated by Lewin's enthusiasm resulted in the isolation of the principal psychoactive component in 1897. Arthur Heffter, Lewin's colleague and rival, made this identification by systematically ingesting a number of alkaloid "fractions" made from peyote; as in the case of psilocybin later, animal testing had been inconclusive as to their various psychoactives. Heffter named the isolate compound "mezcalin" (which soon became "mescaline") and reported that "mescaline hydrochloride, 0.15 g, produces a pattern of symptoms which differs in only a few respects from the one obtained with the drug (peyote)."

Over time, scientific interest in mescaline - first synthesized in 1919 by Ernst Späth - supplanted further investigations of peyote. The last extensive study in this period of the cactus' mental effects was reported in 1927 by the French psychologist Alexandre Rouhier, who caused a stir with his accounts of the "exotic" visions experienced by his subjects.

Exerpt from Peter Stafford's Third Expanded Edition of Psychedelics Encyclopedia, (1992, p. 110).

Image from Old Mescaline Vial

For more about mescaline and to see Mann Research Laboratories' competition, check out Merck's Mescaline Sulfate Bottle

Mann Research Laboratories Mescaline Hydrochloride Bottle.jpg