Sharp & Dohme Cannabis Tincture

Among the reasons for the decline of the medical use of cannabis in the first half of the twentieth century were the pharmacokinetic properties of THC in oral preparations (tincture, fatty extracts). With oral use use, cannabis effects commence in a delayed and erratic manner, making it difficult to titrate the required dose. Overdosing and underdosing of medicinal cannabis preparations of unknown THC content were the inevitable consequences often described by physicians of the 19th century.

A basic understanding of the pharmacokinetic properties of cannabinoids is necessary to comprehend many issues in context with their medical use, e.g., interactions between cannabinoids and metabolic interactions of cannabinoids with other drugs, differences in onset of action and differences in systemic bioavailability between the oral, sublingual, and rectal route of administration and inhalation.

From Russo and Grotenhermen (Eds.) (2006) Handbook of Cannabis Therapeutics, (p. 69)

Modern scientific literature documenting the relative rapid onset of action of tinctures and their safety profile:

The preparation has onset of activity in 15 to 40 min. which allows patients to titrate dosing requirements according to pain levels or other symptoms with an acceptable profile of adverse events (p. 1732).

Russo, B., Guy, G. W., & Robson, P. J. (2007). Cannabis, pain, and sleep?: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine.Chemistry & Biodiversity, 4, 1729-1743.

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Image from Antique Cannabis Book, Chapter 4

Sharp & Dohme Cannabis Tincture